Of the various pemphigus diseases in existence, the P.vulgaris is the most common with an incidence of 0.1-0.5 in 100?000. This auto-immune blistering disease first occurs mainly between the ages of 40 and 60. It manifests as lesions in the oral mucosa which are followed by skin lesions after some months. The bullae, or other general erosions, which are predominantly located on the buccal mucosa, are very painful, may be pruritic and are usually attended by a burning sensation. On the skin, the lesions are fragile blisters which rupture easily and look more like crusted erosions. The Nikolsky?y sign is positive. The general condition may deteriorate. Appropriate immunosuppressive agents are immediately indicated.